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Animals were not used for multiple experiments as two of the three experiments were non-survival (due to the blood collection following DMRS and the urethane anesthesia used for fMRI) and incompatible (DMRS and PET both required labeled glucose injection, the DMRS and fMRI signals may interfere with each other, and fMRI required different anesthesia than the other two experiments)

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The Company continues to expect cash runway through the end of 2026, which will support the completion of recruitment for the pivotal Phase 3 LUCIDITY clinical trial of avexitide in PBH expected in 2025, with a data readout anticipated in the first half of 2026

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