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Cardiomyocytes in CAD patients exhibit particular vulnerability to ferroptosis under adverse conditions such as ischemia and hypoxia, leading to cellular dysfunction and compromised cardiac performance (7)

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This is supported by a recent study that showed an age-dependent decline in both circulating acyl-ghrelin and growth hormone levels in older adults (aged 62-74 years, BMI range 20.9-29 kg/m 2 ) compared to young adults (aged 18-28 years, BMI range 20.6-26.2 kg/m 2 ) (470)