Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AQ amodiaquine AQ-SG 5-glutathion- S -yl-amodiaquine AQ-QI amodiaquine-quinoneimine BSO L -buthionine-sulfoximine CDNB 1-chloro-2, 4-dinitrobenzene CYP cytochromes P450 DEAQ N -desethylamodiaquine DEAQ-SG 5-glutathion- S -yl- N -desethylamodiaquine DEAQ-QI N -desethylamodiaquine-quinoneimine DMEM Dulbeccos modified Eagle medium DMF N,N -dimethylformamide ER endoplasmic reticulum FBS fetal bovine serum GSH glutathione GSSG glutathione disulfide GST glutathione S -transferase H 2 O 2 hydrogen peroxide HClO 4 perchloric acid HRP horseradish peroxidase NQO1 NAD(P)H:quinone oxidoreductase 1 NAPQI N -acetyl- p -benzoquinonimine PBS phosphate-buffered saline QI quinoneimine
No turned capsules for extended periods of time
Tendon and Ligament Repair Both peptides have published preclinical data in tendon and ligament injury, and this is the model class where stacking is most often discussed
These encompass the optimization of the dosage and administration regimen of therapeutic agents, the enhancement of tumor models to more accurately mimic the human tumor microenvironment, the indepth elucidation of the mechanism of ICD for the development of novel NDDSs, and the resolution of issues related to the quality control and largescale production of NDDSs
Common side effects are mild and local, such as injection-site redness or irritation, and vary by peptide
