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The dose relationships used in clinical practice come from indirect comparisons, primarily the SURPASS-2 trial data and accumulated clinical experience

Normal levels for NAD + , NADH, GSH pool and GSSG were determined from frozen blood samples of healthy donors

This mechanism is supported by Phase 3 trials (SURMOUNT series) enrolling over 12,000 participants, with documented reductions in body weight and improvements in cardiovascular risk markers

This information should be interpreted with a qualified healthcare provider as part of a broader clinical evaluation, not as a predictor of exact medication response

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