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The PI3K/Akt axis activated by IGF1R is protective against ischemic injury in cardiac models, and LR3 has been used as a tool in cardioprotection studies, often in conjunction with other research compounds for combined mechanism investigation

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[1] Anatomic Sites Anatomic sites must be selected carefully for intramuscular injections and include the ventrogluteal, vastus lateralis, and the deltoid

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Oppenheimer 2015, pp