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Disclosures: Michalak and colleagues report receiving funding from Novo Nordisk

GPX3 was mainly enriched in TNF- mediated NF-B signaling, steroid metabolism, and fatty acid metabolism pathways ( Figure 6C ), while MYC was primarily enriched in chromoprotein phosphorylation, TGF- binding, and TNF- mediated NF-B signaling ( Figure 6D )

Pilot clinical studies and case reports describe nausea in 65% of subjects at doses above 0,5 mg (resolution 2-4 h post-injection), flushing in 55%, transient increases in blood pressure and tachycardia in 40-60% of subjects, with peak acute effects occurring 90-120 minutes post-dose

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Evidence of polygenic adaptation to high altitude from Tibetan and Sherpa genomes