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It is also important to note that the use of glutathione as a skin lightening agent is off-label and can be associated with potential adverse effects and interactions with other skin products

Omega-3 fatty acids may also be helpful but are especially impactful on triglycerides

In its briefing materials, FDA staff concluded the evidence weighed against adding these peptides, citing limited proof of effectiveness, gaps in how the substances are chemically characterized, and unresolved questions about impurities and immune reactions