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GLP-1 may decrease sodium reabsorption, thus increasing NaCl delivery to the macula densa

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Were comparing results from separate trials with different participants, which has limitations: Different inclusion/exclusion criteria Different trial durations (68 vs 72 weeks) Different geographic populations Different lifestyle intervention protocols What Doctors Say: Most weight loss physicians report that both medications are highly effective

Since the FDA ruled theres no longer a shortage of semaglutide and tirzepatide, compound pharmacies increasingly rely on custom doses and formulations, such as mixing the medication with vitamins or using new pills or tinctures

Furthermore, higher protein intake appears to help preserve lean body mass during energy restriction