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Typically, the initial treatment for B12 deficiency involves a higher dose, followed by regular maintenance injections

The SURPASS trial series demonstrated tirzepatide produces 20-22% weight loss over 68 weeks, outperforming semaglutide (14% loss) and previous GLP-1 only treatments

These include the following: Health conditions One consideration for long-term use of semaglutide is ongoing health conditions and chronic diseases

The key differences come down to regulation, consistency, and access : Ozempic is FDA-approved and clinically studied, while compounded semaglutide offers more flexibility and affordability but its quality depends on where its made