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Nevertheless, the development of an efficient GPx mimic for countering radiation toxicity may also face challenges like non-targeted radioprotection in cancerous cells, poor bioavailability, and poor metabolic stability [39]

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Similar content being viewed by others Introduction The cellular defense against ferroptosis occurs primarily through four mechanisms with distinctive subcellular locations: GPX4 utilizes reduced glutathione (GSH) to detoxify lipid hydroperoxides in both the cytosol and mitochondria 1,2

Skin Protection: Protects the skin from UV damage