Semaglutide Sodium (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM)
In STEP 1, 1,961 nondiabetic adults with overweight or obesity achieved an average 14.9% weight loss over 68 weeks when semaglutide was combined with lifestyle changes.20 STEP 2 examined 1210 individuals with T2DM and showed a more modest average weight loss of 9.6%, possibly due to insulin resistance and the influence of other diabetes medications.21 STEP 3 introduced a more intensive lifestyle intervention to participants who were overweight or obese but without T2DMincluding a calorie-restricted diet and behavioral supportand resulted in slightly higher weight loss amongst the 611 study participants, averaging around 16%.22 The STEP 4 trial included 811 individuals who were overweight or obese without diabetes and assessed the impact of discontinuing semaglutide after 20 weeks
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Mois E, Negoi S, Corneci D
