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In this light, the dissection of the complex association between dysmetabolism and PDAC, with a specific focus on stroma, and in particular on P4HA1 role, could help to unveil novel targets for prevention, early diagnosis and intervention aimed at reducing incidence and improving PDAC prognosis

In preclinical in vitro work, GIPR signalling has been associated with lipid partitioning in adipocyte models and potentiation of insulin secretion under hyperglycaemic conditions

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Planta Med 71(5):416419 Wang L, Wang X, Zhu XM, Liu YQ, Du WJ, Ji J, He X, Zhang CF, Li F, Guo CR, Wang CZ, Yuan CS (2017) Gastroprotective effect of alkaloids from cortex phellodendri on gastric ulcers in rats through neurohumoral regulation

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