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doi: 10.3390/ijms222111644 170

Clinical Perspective The panel concluded that the benefits of GLP-1RAs far outweigh potential ocular risks, given their proven: ~11.5 % HbA1c reduction 515 % weight loss (SURPASS & STEP programs) ~1426 % relative risk reduction in major CV events Hence, appropriate screening, not avoidance, should guide practice

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This does not constitute a guarantee of specific results

In 2017, a meta-analysis of nineteen studies (two RCTs, ten cohorts, seven case-control studies) involving patients with T2DM showed that metformin reduces the risk of HCC by 48% in patients treated with metformin (OR = 0.52