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Ng and colleagues synthesized them, added a tyrosine at the start for better stability, and obtained AOD-9604 , Anti-Obesity Drug 9604, the code name of the development program

doi: 10.1038/s41467-024-53264-8 98 WangJPCernyAAsherDRKurt-JonesEABronsonRTFinbergRW

AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

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