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The protein encoded by the transcription factor 7like 2 (TCF7L2) gene is TCF4, which plays an important role in the Wnt signalling pathway and promotes the synthesis and secretion of glucagon-like peptide-1 (GLP-1), which in turn lowers blood glucose levels

Semaglutide GLP-1 works by reducing hunger and controlling appetite, making it easier to stick to a healthy eating routine

Insulin secretion is biphasic, comprising an initial rapid release, followed by a slower, sustained phase

2022;29:10115.e110

By mimicking the activity of the hormone GLP-1, it influences the brain to regulate appetite and food intake and reduce food cravings