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After that, the solid gold shell was scratched into solid AuNS (HAuNS), and to create HAuNS@PEG-bio, it was further altered using biotin-PEG-SH (PEG-bio)

IGF-1 LR3 activates the same downstream signaling cascades as native IGF-1, including PI3K/Akt and MAPK/ERK pathways, which are central to cell growth, proliferation, and survival

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