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For frozen shoulder specifically, relaxin-2 targets the actual pathology more directly than any other peptide, though availability remains limited

It is not approved for human or veterinary use, and is not intended for diagnostic, therapeutic, or clinical applications

Accordingly, we stated in the CY 2026 PFS proposed rule that we believed separately comparing ASM participants' final scores for each of the ASM targeted chronic conditions would provide more meaningful performance comparisons (90 FR 32607)

BioMed Research International, 2015 , 648108

Standard research cycles run 812 weeks with 46 week washout periods to prevent receptor downregulation