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The protocols in our animal studies were approved by the Institutional Animal Care and Use Committee of Chang Gung University

10.1016/j.jddst.2015.12.008 152 LiH

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And I think that point has to do with the intermittent challenging of yourself and whether that is through temperature changes, like cold or heat, or through other types of stressors, like physical activity or perhaps even dietary compounds that are found in plants, these are things like polyphenols or flavanols