Doubling up can cause higher exposure and increase side effects
Workspan Daily article Strategies to Deliver Diabetes Support and Solutions for Employees, Workspan Daily article Fifty-one percent of employers in a recent benefits study cited glucagon-like peptide-1 (GLP-1) diabetes and weight-loss medications as the top driver of prescription drug spend, surpassing even cancer and autoimmune treatments
456 At this docking site, JAK phosphorylates STAT, causing STAT to dissociate from the receptor and form homodimers or heterodimers through SH2 domain-phosphotyrosine interactions
Yusuf, M., Khan, M., Khan, R
For very high disease activity, you may even go right to an IL-17 blocker and bypass anti-TNFs, which have not proven as effective for ankylosing spondylitis as they have been for other types of inflammatory arthritis