2 Vitamin B1 Vitamin B1, or thiamine, is an essential nutrient obtained through dietary sources such as whole-grain products, brown rice, meat, vegetables, and fruits (, )
An enzyme called glutathione peroxidase 4 (GPX4) uses glutathione to neutralize the lipid peroxides that cause ferroptosis
The observed susceptibility in the GSH-deficient pad2-1 mutant suggests an indispensable role for GSH in plant defense, which encourages us to further investigate whether GSH acts as wound signal to trigger long distance calcium-based defense signaling events
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Low GSH levels could also increase viral replication, pro-inflammatory cytokine release, endothelial damage, and immune-thrombosis, which is a hyper-coagulative clinical condition that could exacerbate morbidity and mortality in COVID-19 and PASC 598
