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PLoS ONE 10 , e0120674 (2015)

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Consequently, up to 66% of liver transplant recipients are affected by diabetes which has profound impact on liver allograft and patient survival

Numerous later studies have shown the association between increased plasma TMAO levels with a higher risk of cardiovascular events [63,64,65,66]

Clinicians should monitor patients for potential adverse effects including pancreatitis (severe, persistent abdominal pain), gallbladder disease (right upper quadrant pain), diabetic retinopathy complications (especially with rapid glucose improvement), acute kidney injury with dehydration, and hypoglycemia when combined with insulin or sulfonylureas