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In addition to caffeines role in the inflammatory context with beneficial effects, such as antioxidant and anti-inflammatory actions, it is important to highlight that other mechanisms of action of caffeine have been associated with its ability to control psychiatric disorders

Acknowledgments The Toxic Metals in Canadians scoping review was supported by the Canadian Institutes of Health Research

Trial Population: The SELECT trial enrolled over 17,600 adults who had pre-existing cardiovascular disease and were overweight or obese, but did not have diabetes

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