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Thus, while e-cigarettes eliminate many combustion-related toxins present in conventional cigarettes, they still emit a complex array of hazardous chemicals, including nicotine, volatile organic compounds, nitrosamines, polycyclic aromatic hydrocarbons (PAHs), aldehydes, and heavy metals [123]

Pharmacoresistance was defined as the failure of two therapeutic attempts with antipsychotic medications from two different receptor groups after a sufficient time

Smoking contributes to air pollution (via toxic smoke and thirdhand smoke), water pollution (from chemicals in cigarette butts), and land pollution (through soil contamination and deforestation for tobacco cultivation).

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