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The groups issued a joint statement on 15 September 2015 arguing that there is no circumstance in which it is better for a smoker to continue smoking rather than switch to vaping

Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention

If you take more edibles while waiting for them to kick in, it can lead to over-intoxication

This effect is best understood in the context of gene promoters where DNA methylation can impair physical binding of transcription enhancers and promote the recruitment of methyl-CpG-binding domain proteins that increase chromatin condensation and thus decrease the DNA accessibility for the transcriptional machinery (Portela and Esteller, 2010)