Both hormones are known to participate in intraislet crosstalk, with glucagon acting on betacell GLP1Rs and glucagon receptors to enhance insulin release, and GIP promoting glucagon secretion from alphacells (Drucker and Holst 2023)
Your healthcare provider will assess your individual circumstances, including your complete medication list, medical history, and the severity of your symptoms
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If you cannot tolerate a dose level after two attempts, your current dose may be your optimal maintenance dose
For the efficacy estimandi, at 52 weeks, tirzepatide led to a mean apnea-hypopnea index (AHI) reduction from baseline of 27.4 events per hour compared to a mean AHI reduction from baseline of 4.8 events per hour for placebo