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However, clinical trials are what establish whether a treatment produces reliable outcomes across large populations, and professional guidelines define the standard of care physicians follow in practice
Patients may experience nausea, diarrhea, abdominal pain, constipation, or vomiting until their body becomes more accustomed to their medications
Consequently, NAC has strong sulphur like odour, which is completely normal
Whilst moderate dehydration doesnt directly impact the effectiveness of the medication, severe dehydration could potentially affect overall metabolism and medication absorption
Even the combination regimen of anti-CTLA4 (ipilimumab) and anti-PD1 (nivolumab) agents merely witness a slight increased ORR to 37% with PFS at 5.9 month (136, 175)
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