The signaling pathways by which the Fas/FasL system accelerates oocyte aging
Nrf2 Pathway Activation Glutathione depletion triggers activation of Nrf2 (nuclear factor erythroid 2-related factor 2), the master transcription factor for antioxidant gene expression
Moreover, most clinical cancer therapies, including conventional chemotherapies 8 , radiotherapy 9 , or recent immune therapies 10,11 , have also been reported to undermine female fertility in various ways, which further distracts researchers attention on NRTP-induced ovarian damage
Oxidative stress and accelerated aging are the clearest targets, since glutathione is the front-line molecule that neutralizes free radicals before they damage mitochondria and DNA
Acting at these steps should indeed avoid the accumulation of sulfite and sulfide, which may otherwise be toxic