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When it functions in this manner, it is closely linked to the development of metabolic syndrome, with lower levels being associated with impaired lipid profiles, insulin resistance, higher blood glucose levels and an increased risk of obesity and cardiovascular disease

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In practice, and in view of clonazepams adverseeffect profile, a short, timelimited course of the combination during the initial 4 weeks may be considered when rapid quality of life improvement is prioritized, whereas liquid NAC monotherapy is likely sufficient over an 8week horizon for patients for whom minimizing benzodiazepine exposure is preferred

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