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Biochemistry 55, 42864294

During oxidative stress, ROS directly interact with amino acid side chains (mainly lysine, arginine, proline, and threonine), or peptide bonds in the polypeptide chain are broken and carbonyl groups are formed inside the polypeptide structure (168)

We propose that nebulization of 3000 mg per day of NAC or GSH may suffice in controlling the aggravation of oxidative stress and inflammation arising from the severe cytokine storm in pulmonary structures (Fig

As an example of its mechanism of action, SAMe supplementation was shown to inhibit DNA demethylase, DNMT1 activity, and demethylation of PS1, a prime gene product involved in amyloidogenesis [143], as discovered in transgenic AD mice