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By combining neuroimaging metrics (e.g., cortical thickness, functional connectivity), body fluid biomarkers (e.g., NfL, A 142 /tau ratios), genetic variants (e.g., apolipoprotein E, CD36, TREM2), and cognitive/clinical profiles, AI-based models can construct multidimensional representations of disease states

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First, we characterized the plasma EV proteomes in a subset of patients for whom sufficient plasma was available at each visit

Moreover, the presence of GSH in the tumour microenvironment argues against the feasibility of targeting these pathways for cancer therapy