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In a poor nutritional state, GSH reserves become easily exhausted and hepatic glucouronidation is stunted, leading to decreased levels of available GSH that would otherwise be scavenged for formation of reactive metabolites in phase I of APAP metabolism

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D.BoverisA.2005Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice.289139213990363-6119 40

10.1056/NEJMoa1606468 130