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Severe hypoglycemia was not reported, and gastrointestinal events were the most frequent adverse effects in the tirzepatide group ( Tirzepatide was compared to once-weekly oral semaglutide in the SURPASS-2 study, an open-label, phase 3 clinical trial with a 40-week follow-up that enrolled T2DM patients with a BMI of 25 kg/m 2 and an HbA1c of 710.5% despite taking at least a 1500 mg dose of metformin

In regulated research and clinical trial settings, lyophilised retatrutide powder is typically stored at 20C for long-term stability, or at 80C if specified by the trial sponsor's protocol

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Elderly Patients Older adults may use the medication with monitoring for treatment response and tolerance

Susan Massick, a dermatologist at Ohio State University, told NBC News.