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The G-protein coupled receptors activate phosphoinositide-specific phospholipase C (PLC)

Based on the formation constant of Fe(III)-curcumin of 10 22 M 1, 67 , it has been calculated that the pFe 2+ (pM) of curcumin is 16.6 (at pH 7.4 for 10 M curcumin and 1 M Fe 2+, 68 )

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Yet, the short duration of the study did not permit a conclusion on whether the lowering of homocysteine through B-vitamin supplementation could have long-term benefits on bone strength and fracture risk (119)

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