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In those who require acetylcysteine, 2 hours before completion of infusion check ALT/AST and paracetamol concentration (in those with high initial paracetamol concentrations greater than double the 150mg at 4 h nomogram line) to determine need for ongoing acetylcysteine

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Reduced overall food intake, less fluid, and slower gut motility (how quickly the intestines move) can all stack the deck