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Neuroscience 150 , 251259 (2007)
Both of these primitive chaperones, CRAM-1 and MOAG/SERF1, impair survival and could act as non-competitive inhibitors of the proteasome in an age-dependent manner relevant to AD (Ayyadevara et al., The high levels of oxidized proteins detected in the brains of AD patients are an indirect indication of proteasome impairment, since this proteolytic complex degrades the majority of oxidatively modified proteins (Grune et al., 2004)
NNF18CC0034900)
The shearing force from shaking denatures proteins and peptides
The purpose of this review was to provide a brief account of these developments and to discuss the possible mechanisms involved
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