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Participants received weekly injections of semaglutide and followed basic lifestyle advice, such as eating healthier and exercising

Several meta-analyses have reported that serum BDNF levels are significantly decreased in both the manic and depressive phases of bipolar disorder [46,47,48]

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For example, in a study, participants on semaglutide lost, on average, 14.9% of their body weight compared to 2.4% with placebo

SURMOUNT-5: the head-to-head comparison with Wegovy SURMOUNT-5 is particularly revealing: a direct head-to-head comparison between Zepbound and Wegovy over 72 weeks