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The PASADENA study and its subsequent TTE analysis have opened up a promising avenue for evaluating disease-modifying therapies in PD

The semaglutide arm activates the GLP-1 receptor an incretin receptor expressed in the pancreas, gut and brain enhancing glucose-dependent insulin secretion, slowing gastric emptying and signaling satiety in hypothalamic appetite centers

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Patients should follow healthcare provider instructions and manufacturer guidelines to avoid temperature extremes that may impact medication quality