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In mammals, the action and biological influence of OMEs have been studied in the rabbit, as a model, since several years

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rHN also co-localized with Bax, a pro-apoptotic protein and known HN-binding partner, suggesting functional interactions within mitochondria

(2017) ( Epub 2017/03/16 )

While Nogo-A signaling is mainly associated to myelination and inhibition of synaptic and axonal plasticity in adult mammalian CNS, it has also been found to correlate with numerous homeostatic and pathological mechanisms, such as found in schizophrenia (51), stroke (52), beta-amyloid disease (53), spinal cord injury (54) and amyotrophic lateral sclerosis (55, 56)