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Further investigation of the intestinal microbiome metabolism of orally supplemented l-carnitine in patients with IEMs is needed to answer the following questions raised by this study: (1) Does chronic oral l-carnitine supplementation increase the risk of atherosclerosis in individuals with organic acidemias

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Slides were mounted with Mowiol 488 (Merck) and images acquired with a Zeiss Axio Imager A2 fluorescence microscope

Choosing the right treatment depends on absorption, severity of deficiency, lifestyle, and underlying medical conditions

AIs most impactful applications are likely to remain largely behind the scenes, improving pattern recognition, trial design, safety monitoring, and decision support rather than replacing clinical judgment, said Dr