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The new approval for Retevmo, which was previously authorized to treat patients 12 and older with RET-positive thyroid cancers, is based on a single-arm study that showed an overall response rate of 48%, with a median duration of response not reached after 12 months of follow-up

doi: 10.1093/jxb/erj175

Notably, weight loss curves had not yet plateaued at 48 weeks, suggesting that longer treatment could produce even greater results

They dont replace the fundamentals of good sleep, adequate protein intake, resistance training, sun protection and avoiding lifestyle factors that prematurely age people

This lack of specificity complicates the interpretation of treatment effects and underscores the need to develop more refined, translation-oriented behavioral paradigms