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Without it, cells become more resistant to insulin signaling, creating a metabolic environment where blood sugar regulation deteriorates and the body becomes more efficient at converting excess glucose to stored fat

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In the endometrium, changes in intracellular calcium are regulated by specific ion channels and transporters

Critically, elevated fasting circulating BCAAs in obesity and insulin resistance primarily indicate impaired peripheral catabolic disposal and altered inter-organ flux, not simply excessive dietary intake