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In trying to protect your mind from the neuro-chemical influence of the toxic natural pesticide nicotine, in some brain regions it actually desensitized important neuro-chemical circuits by reducing neurotransmitter receptor sites (down-regulation), in other regions by increasing the number of receptors (up-regulation), and still others by diminishing the number of transporters

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This epidemic costs our state and local governments hundreds of millions of dollars in tax revenue annually, deprives tax-collecting retailers of legitimate business and siphons away private-sector jobs, he said