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Research suggests that the combination of B12 with local anesthetics can be effective in treating myofascial pain syndrome while offering similar pain relief to corticosteroids

Under homeostatic conditions, Keap1 forms part of an E3 ubiquitin ligase, which tightly regulates the activity of the transcription factor Nrf2 by targeting it for ubiquitination and proteasome-dependent degradation

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Some patients benefit from staggered dosing while others respond best to simultaneous administration

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