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Alternatively, preclinical studies using leptin-deficient animals ( ob/ob mice) demonstrated that restoring plasma leptin concentration to normal improved heart function after MI, and that these beneficial effects were associated with reductions in cardiac inflammation and apoptosis [13, 14] and activation of anti-hypertrophic pathways in obese animals with left ventricle (LV) hypertrophy [8]

"Nonsteroidal selective androgen receptor modulator Ostarine in cancer cachexia." Future Oncology 5.8 (2009): 1211-1220

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