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Pannacciulli N, Le DS, Salbe AD, Chen K, Reiman EM, Tataranni PA et al

For example, remaining at a lower dose for an additional two to four weeks before escalating may allow the digestive system to adapt

1 Oral semaglutide for type 2 diabetes has been available as Rybelsus in a different formulation and set of doses

Ann Surg 2007

Retatrutide Side Effects Are Similar to Existing Diabetes and Obesity Injectables The most common side effects for retatrutide were: Nausea (16 to 27 percent of participants, depending on dosage, compared with 3.7 percent of those taking a placebo) Diarrhea (19 to 23 percent, compared with 5 percent taking a placebo) Vomiting (16 to 18 percent, compared with 2 percent taking a placebo) Nerve issues (2 to 4 percent, compared with none taking a placebo) Between 2 and 5 percent of participants on retatrutide stopped taking it before the trial ended, with a greater risk of stopping among those who took the highest dose