Selenium-Rich Foods: Brazil nuts, sardines, and grass-fed beef provide selenium, a mineral that helps the body produce an enzyme called glutathione peroxidase
Sometimes patients are seen with agonizing muscle and joint pain preventing them from even getting out of bed
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The high response rate to treatment with IBAT (odevixibat) in these patients suggests that in PFIC4, despite tight junction dysfunction, there is a regular passage of BAs from the hepatocytes to the biliary tree and the bowel, allowing odevixibat to interrupt the enterohepatic circulation and decrease the recirculating BA pool [1, 42, 47]
The basis of this decontamination method is to increase the rate at which the water in the body is replaced with new water
