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During the trial, additional anti-diabetic medication was initiated as an add on to randomized treatment by 1.9% and 1.2% of patients randomized to semaglutide tablets 14 mg and empagliflozin 25 mg, respectively

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice

When prescribed appropriately, it may help: Results vary by individual and depend on adherence and lifestyle factors

The use of semaglutide was associated with a higher relative risk and frequency of most adverse effects evaluated

The cellular protection of -cells and hepatocytes is well-supported by in vitro and animal data, anti-steatohepatitis effects are supported, while reversal of established fibrosis remains uncertain pending more definitive phase 3 outcomes (Loomba et al., 2023