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Vergs, B

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Even medications taken years before the study exhibited associations with changes in the microbiome, including antibiotics, psychiatric sedatives, antidepressants, proton pump inhibitors (PPIs), beta-blockers, and benzodiazepine derivatives, according to the findings

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They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology