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Insulin exerts its cellular effects through two primary pathways: the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, the latter of which plays a crucial role in cell growth and survival

This aniline has been detected in the plasma of patients after oral administration of the drug 5 and exposure has been associated with hepatotoxicity 2

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The human data for addiction is observational and the mechanistic data is looking at rodents

[DOI] [PMC free article] [PubMed] [Google Scholar] Arslanian SA, Hannon T, Zeitler P, Chao LC, Boucher-Berry C, Barrientos-Prez M, Bismuth E, Dib S, Cho JI, Cox D