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Therefore, the downstream response blocked by MC4R deficiency could affect the anorexigenic effect of the GLP-1analog, but its effect has not been confirmed yet

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The ions and small molecules move across the IMM following the concentration gradient

However, clinical experience has shown that linker instability and side effects from systemic exposure to ADC payloads remain a significant challenge, with both off-target and on-target toxicities frequently resembling those of the unconjugated cytotoxic agents 6,7

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